Chai-2

Model Family

Multimodal generative molecular-design models for zero-shot antibodies, nanobodies, and miniprotein binders.

Releases

Jun 30, 2025Chai-2 achieves double-digit de novo antibody hit ratesChai-2Benchmark result

Chai reported a 16% antibody binding rate, hits for half of tested targets, and a 68% wet-lab hit rate for miniprotein binders.

Jun 30, 2025Chai-2 unveiledChai-2 · 2Model release

Chai Discovery introduced a model family for zero-shot de novo antibody, nanobody, and miniprotein design.